USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P51570 USC-OGP 2-DE database:  P51570 P51570 General information about the entry View entry in simple text format Entry name GALK1_HUMAN Primary accession number P51570 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Galactokinase; EC=2.7.1.6; AltName: Full=Galactose kinase;. Gene name Name=GALK1 Synonyms=GALK Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0426: pI=5.90; Mw=40609 PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0717: pI=5.89; Mw=40117 PLATELET_6-11 {PLATELET 6-11} Homo sapiens (Human)   map experimental info   PLATELET_6-11 MAP LOCATIONS: SPOT OGP-0956: pI=5.81; Mw=40264 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1193: pI=6.19; Mw=41038 SPOT OGP-1194: pI=6.41; Mw=40578 Cross-references UniProtKB/Swiss-Prot P51570; GALK1_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name GALK1_HUMAN Primary accession number P51570 Secondary accession number(s) B2RC07 B4E1G6 Sequence was last modified on  October 1, 1996 (version 1) Annotations were last modified on  March 15, 2017 (version 174) Name and origin of the protein Description RecName: Full=Galactokinase; EC=2.7.1.6; AltName: Full=Galactose kinase; Gene name Name=GALK1 Synonyms=GALK Encoded on Name=GALK1; Synonyms=GALK Keywords 3D-structure; Alternative splicing; ATP-binding; Carbohydrate metabolism; Cataract; Complete proteome; Direct protein sequencing; Disease mutation; Galactose metabolism; Kinase; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Transferase. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL U26401; AAA96147.1; -; mRNA EMBL L76927; AAB51607.1; -; Genomic_DNA EMBL AK303832; BAG64778.1; -; mRNA EMBL AK314890; BAG37404.1; -; mRNA EMBL BT007005; AAP35651.1; -; mRNA EMBL AC087749; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL CH471099; EAW89316.1; -; Genomic_DNA EMBL BC001166; AAH01166.1; -; mRNA CCDS CCDS11728.1; -. [P51570-1]; . RefSeq NP_000145.1; NM_000154.1. [P51570-1]; . UniGene Hs.407966; -; . PDB 1WUU; X-ray; 2.50 A; A/B/C/D=2-392 PDB 1YH7; Model; -; A=1-392 PDBsum 1WUU; -; . PDBsum 1YH7; -; . ProteinModelPortal P51570; -; . SMR P51570; -; . BioGrid 108857; 16; . IntAct P51570; 16; . MINT MINT-4999410; -; . STRING 9606.ENSP00000225614; -; . BindingDB P51570; -; . ChEMBL CHEMBL1293257; -; . DrugBank DB04395; Phosphoaminophosphonic Acid-Adenylate Ester; . iPTMnet P51570; -; . PhosphoSitePlus P51570; -; . BioMuta GALK1; -; . DMDM 1730187; -; . OGP P51570; -; . REPRODUCTION-2DPAGE IPI00019383; -; . EPD P51570; -; . PaxDb P51570; -; . PeptideAtlas P51570; -; . PRIDE P51570; -; . DNASU 2584; -; . Ensembl ENST00000225614; ENSP00000225614; ENSG00000108479. [P51570-1]; . Ensembl ENST00000588479; ENSP00000465930; ENSG00000108479. [P51570-1]; . GeneID 2584; -; . KEGG hsa:2584; -; . CTD 2584; -; . DisGeNET 2584; -; . GeneCards GALK1; -; . HGNC HGNC:4118; GALK1; . HPA HPA007094; -; . HPA HPA016960; -; . MalaCards GALK1; -; . MIM 230200; phenotype; . MIM 604313; gene; . neXtProt NX_P51570; -; . OpenTargets ENSG00000108479; -; . Orphanet 79237; Galactokinase deficiency; . PharmGKB PA28533; -; . eggNOG KOG0631; Eukaryota; . eggNOG COG0153; LUCA; . GeneTree ENSGT00530000063433; -; . HOGENOM HOG000241100; -; . HOVERGEN HBG051695; -; . InParanoid P51570; -; . KO K00849; -; . OMA RREECAQ; -; . OrthoDB EOG091G06HT; -; . PhylomeDB P51570; -; . TreeFam TF354326; -; . BRENDA 2.7.1.6; 2681; . Reactome R-HSA-70370; Galactose catabolism; . SABIO-RK P51570; -; . UniPathway UPA00214; -; . EvolutionaryTrace P51570; -; . GenomeRNAi 2584; -; . PRO PR:P51570; -; . Proteomes UP000005640; Chromosome 17; . Bgee ENSG00000108479; -; . CleanEx HS_GALK1; -; . ExpressionAtlas P51570; baseline and differential; . Genevisible P51570; HS; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0005524; F:ATP binding; IDA:UniProtKB; . GO GO:0004335; F:galactokinase activity; IDA:UniProtKB; . GO GO:0005534; F:galactose binding; IDA:UniProtKB; . GO GO:0019402; P:galactitol metabolic process; IEA:Ensembl; . GO GO:0019388; P:galactose catabolic process; TAS:Reactome; . GO GO:0006012; P:galactose metabolic process; IMP:UniProtKB; . GO GO:0061623; P:glycolytic process from galactose; IEA:Ensembl; . Gene3D 3.30.230.10; -; 1; . Gene3D 3.30.70.890; -; 1; . InterPro IPR000705; Galactokinase; . InterPro IPR019741; Galactokinase_CS; . InterPro IPR019539; GalKase_gal-bd; . InterPro IPR013750; GHMP_kinase_C_dom; . InterPro IPR006204; GHMP_kinase_N_dom; . InterPro IPR006203; GHMP_knse_ATP-bd_CS; . InterPro IPR006206; Mevalonate/galactokinase; . InterPro IPR020568; Ribosomal_S5_D2-typ_fold; . InterPro IPR014721; Ribosomal_S5_D2-typ_fold_subgr; . PANTHER PTHR10457:SF17; PTHR10457:SF17; 1; . Pfam PF10509; GalKase_gal_bdg; 1; . Pfam PF08544; GHMP_kinases_C; 1; . Pfam PF00288; GHMP_kinases_N; 1; . PIRSF PIRSF000530; Galactokinase; 1; . PRINTS PR00473; GALCTOKINASE; . PRINTS PR00959; MEVGALKINASE; . SUPFAM SSF54211; SSF54211; 1; . SUPFAM SSF55060; SSF55060; 1; . TIGRFAMs TIGR00131; gal_kin; 1; . PROSITE PS00106; GALACTOKINASE; 1; . PROSITE PS00627; GHMP_KINASES_ATP; 1; .

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